Zi-Ning Lei Selected Research

ATP-Binding Cassette Transporters (ABC Transporters)

12/2021	Overcoming multidrug resistance by knockout of ABCB1 gene using CRISPR/Cas9 system in SW620/Ad300 colorectal cancer cells.
9/2021	ATP-binding cassette (ABC) transporters in cancer: A review of recent updates.
6/2021	Insights on the structure-function relationship of human multidrug resistance protein 7 (MRP7/ABCC10) from molecular dynamics simulations and docking studies.
1/2021	Overexpression of ABCG2 Confers Resistance to MLN7243, a Ubiquitin-Activating Enzyme (UAE) Inhibitor.
7/2020	The Multidrug Resistance-Reversing Activity of a Novel Antimicrobial Peptide.
1/2020	Tivantinib, A c-Met Inhibitor in Clinical Trials, Is Susceptible to ABCG2-Mediated Drug Resistance.
1/2020	M3814, a DNA-PK Inhibitor, Modulates ABCG2-Mediated Multidrug Resistance in Lung Cancer Cells.
1/2020	Modulating the function of ABCB1: in vitro and in vivo characterization of sitravatinib, a tyrosine kinase inhibitor.
1/2020	Biological evaluation of non-basic chalcone CYB-2 as a dual ABCG2/ABCB1 inhibitor.
1/2020	Sapitinib Reverses Anticancer Drug Resistance in Colon Cancer Cells Overexpressing the ABCB1 Transporter.

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Zi-Ning Lei Research Topics

Disease

37	Neoplasms (Cancer) 01/2022 - 01/2018
3	Breast Neoplasms (Breast Cancer) 01/2022 - 09/2017
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2021 - 01/2018
3	Lung Neoplasms (Lung Cancer) 01/2020 - 01/2020
2	Acute Promyelocytic Leukemia 01/2021 - 09/2017
2	Colonic Neoplasms (Colon Cancer) 01/2020 - 01/2019
2	Melanoma (Melanoma, Malignant) 04/2019 - 01/2019
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 06/2022
1	Type 2 Diabetes Mellitus (MODY) 06/2022
1	Insulin Resistance 06/2022
1	Pain (Aches) 01/2022
1	Osteoarthritis 01/2022
1	Atrial Fibrillation 01/2022
1	Colorectal Neoplasms (Colorectal Cancer) 12/2021
1	COVID-19 12/2020
1	Autoimmune Diseases (Autoimmune Disease) 12/2020
1	Malaria 12/2020
1	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 02/2020
1	Carcinoma (Carcinomatosis) 01/2020
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2020
1	Hematologic Neoplasms (Hematological Malignancy) 01/2020
1	Experimental Arthritis 11/2019
1	Arthritis (Polyarthritis) 11/2019
1	Rheumatic Diseases (Rheumatism) 11/2019
1	Alcoholic Fatty Liver 01/2019
1	Leukemia 01/2019
1	Neoplasm Metastasis (Metastasis) 04/2018

Drug/Important Bio-Agent (IBA)

16	ATP-Binding Cassette Transporters (ABC Transporters)IBA 12/2021 - 01/2018
14	Pharmaceutical PreparationsIBA 01/2022 - 01/2018
11	Adenosine Triphosphate (ATP)IBA 12/2021 - 01/2019
7	Proteins (Proteins, Gene)FDA Link 01/2022 - 03/2013
5	Paclitaxel (Taxol)FDA LinkGeneric 12/2021 - 01/2019
5	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 11/2019 - 09/2017
4	ErbB Receptors (EGF Receptor)IBA 01/2022 - 01/2018
4	Topotecan (Hycamtin)FDA LinkGeneric 01/2021 - 01/2018
4	Antineoplastic Agents (Antineoplastics)IBA 07/2020 - 01/2018
3	Tyrosine Kinase InhibitorsIBA 01/2020 - 01/2018
3	Mitoxantrone (Novantrone)FDA LinkGeneric 11/2019 - 01/2018
2	OTS964IBA 01/2022 - 01/2021
2	Therapeutic UsesIBA 01/2022 - 01/2021
2	Biological ProductsIBA 09/2021 - 01/2020
2	Arsenic Trioxide (Trisenox)FDA Link 01/2021 - 09/2017
2	9 alpha,11 alpha,15 alpha- trihydroxy- 16- phenoxy- 17,18,19,20- tetranorprosta- 4,5,13- trienoic acid (TPT)IBA 01/2021 - 01/2020
2	Member 2 Subfamily G ATP Binding Cassette TransporterIBA 01/2021 - 01/2021
2	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2020 - 11/2019
2	SurvivinIBA 04/2019 - 04/2018
1	Ouabain (G Strophanthin)IBA 01/2022
1	Digoxin (Digitek)FDA LinkGeneric 01/2022
1	palbociclibIBA 01/2022
1	Cyclin-Dependent Kinase 4IBA 01/2022
1	LDL Receptors (LDL Receptor)IBA 01/2022
1	Estrogen ReceptorsIBA 01/2022
1	Letrozole (Femara)FDA LinkGeneric 01/2022
1	cabozantinibIBA 01/2021
1	TAK-243IBA 01/2021
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2021
1	Chloroquine (Aralen)FDA LinkGeneric 12/2020
1	Hydroxychloroquine (Plaquenil)FDA LinkGeneric 12/2020
1	WYE-354IBA 02/2020
1	venetoclaxIBA 02/2020
1	ARQ 197IBA 01/2020
1	Membrane Proteins (Integral Membrane Proteins)IBA 01/2020
1	RN486IBA 01/2020
1	AZ-628IBA 01/2020
1	sitravatinibIBA 01/2020
1	peposertibIBA 01/2020
1	AZD 8931IBA 01/2020
1	ibrutinibIBA 01/2020
1	Netrin ReceptorsIBA 01/2020
1	Agammaglobulinaemia Tyrosine KinaseIBA 01/2020
1	Antimicrobial PeptidesIBA 01/2020
1	Cantharidin (Cantharides)IBA 01/2020
1	Chalcone (Benzalacetophenone)IBA 01/2020
1	Cisplatin (Platino)FDA LinkGeneric 01/2020
1	Biomarkers (Surrogate Marker)IBA 01/2020
1	A-Form DNA (A-DNA)IBA 01/2020
1	ChalconesIBA 01/2020
1	Proto-Oncogene Proteins A-rafIBA 01/2020
1	tetrandrineIBA 11/2019
1	Vincristine (Oncovin)FDA LinkGeneric 11/2019
1	Adenosine Triphosphatases (ATPase)IBA 11/2019
1	Phospholipases A2 (Phospholipase A2)IBA 11/2019
1	fexofenadine (Allegra)FDA LinkGeneric 11/2019
1	regorafenibIBA 01/2019
1	MAP Kinase Kinase Kinase 5IBA 01/2019
1	selonsertibIBA 01/2019
1	tepotinibIBA 01/2019
1	pyridineIBA 01/2019
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2019
1	midostaurinIBA 01/2019
1	Tubulin ModulatorsIBA 01/2019
1	ulixertinibIBA 12/2018
1	Apoptosis Regulatory ProteinsIBA 04/2018
1	dacomitinibIBA 01/2018
1	olmutinibIBA 01/2018

Therapy/Procedure

10	Drug Therapy (Chemotherapy) 12/2021 - 01/2018
4	Therapeutics 09/2021 - 01/2019
1	Fecal Microbiota Transplantation 06/2022
1	Combination Drug Therapy (Combination Chemotherapy) 01/2020
1	Radiotherapy 04/2018